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Ferroptosis: Crosstalk between metabolism and biochemical homeostasis

April 13–15, 2025
Chicago

Ferroptosis is form of cell death that integrates biochemistry and molecular biology related to iron homeostasis, redox biology and diverse aspects of metabolism. Ferroptosis was first reported in the Stockwell lab in 2012, and the field has rapidly grown since then, with more than 10,000 papers on ferroptosis currently in PubMed. This meeting will focus on the biochemical and molecular aspects of ferroptosis and how they relate to normal homeostasis and disruptions of homeostasis. Recent exciting advances in new pathways controlling ferroptosis make a meeting on this topic timely.

Attendees will learn about this emerging area of ferroptosis and how it intersects with biochemistry, molecular biology, cell homeostasis and numerous related fields, such as iron, metabolism and ROS biology. In addition, attendees will meet experts in this set of fields, be able to present their relevant research, get new ideas and form new collaborations in this rapidly growing field.

Organizers

Columbia University
University of Texas Southwestern Medical Center
Memorial Sloan Kettering Cancer Center

Sponsors

Speakers

Aberrant mitochondrial metabolism in Alzheimer’s disease links energy stress to ferroptosis
Scott Ayton, University of Melbourne

Studying and targeting ferroptosis in cancer
Gan Boyi, MD Anderson Cancer Center

Truncated oxidized phospholipids mediate synchronized ferroptosis and contribute to acute kidney injury
Quan Chen, Nankai University

Sculpturing embryos via ferroptotic trigger waves
Sheng-hong Chen, Institute of Molecular Biology Academia Sinica

Ferroptosis regulation by lipid metabolism
Scott Dixon, Stanford University

Understanding the complexity of p53-mediated ferroptosis in tumor suppression
Wei Gu, Columbia University

Targeting metabolism in glioblastoma
Dominique Higgins, University of North Carolina at Chapel Hill

Phospholipid remodeling in ferroptosis and cancer treatment
Xuejun Jiang, Memorial Sloan Kettering Cancer Center

Defensive cell death in plants: Regulating ferroptosis against pathogen invasion
Namsoo Jwa, Sejong University

Selenium’s paradox in the regulation of ferroptosis
Namgyu Lee, Dankook University

Targeting ferroptosis for TNBC therapy
Sima Lev, Weizmann Institute of Science

Iron metabolism in adipocytes – All roads lead to ferroptosis
Philip Scherrer, University of Texas Southwestern Medical Center

Ferroptosis and male infertility: Exploring new therapeutic avenues in reproductive health
Cui Shaojie, Huazhong Agricultural University

The role of selenium deficiency and selenocysteine lyase in ferroptotic cell death
Brianna Shimada, University of Hawaii

Diet, drugs and disease: Ferroptosis as a new therapeutic paradigm
Brent Stockwell, Columbia University

Mechanisms of immunomodulation during ferroptosis
Peter Vandenabeele, VIB

Ferroptosis: The driver for alcoholic liver disease
Jin Ye, University of Texas Southwestern Medical Center

Dissecting NRF2's multifaceted control points in ferroptosis defense
Donna Zhang, Scripps Research Institute

Program schedule

Sunday, April 13
7–9 p.m. Welcome & Session 1
9–10 p.m. Reception
Monday, April 14
9 a.m. – 12 p.m. Session 2
12–2 p.m. Lunch
2–5 p.m. Session 3
5–7 p.m. Poster session
Tuesday, April 15
9 a.m. – 12 p.m. Session 4
12–1 p.m. Lunch
1–4 p.m. Session 5
4 p.m. Adjourn
7:30–9:30 p.m. Annual meeting closing reception

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