91Ó°¿â

Craig Blackstone

, chief of the movement disorders division in the neurology department at Massachusetts General Hospital and professor of neurology at Harvard Medical School, was recognized for identifying the cellular pathogenic mechanisms underlying hereditary spastic paraplegia and providing insight into the basic biology of the endoplasmic reticulum.

Namandjé Bumpus

, chief scientist at the U.S. Food and Drug Administration and a professor of pharmacology at Johns Hopkins University School of Medicine, was recognized for foundational work in drug metabolism and antiviral pharmacology as well as translating fundamental drug metabolism studies to the prediction of patient drug responses. 

Peter Glazer

, professor and chair of therapeutic radiology at Yale School of Medicine, was recognized for discovering that tumor hypoxia causes genetic instability and IDH1 mutations suppress DNA repair in cancers, which cause vulnerability to radiation and PARP inhibitors. Glazer has developed novel drugs for cancer and gene editing, which has led to multiple cancer clinical trials. 

Laura Kiessling

, professor of chemistry at the Massachusetts Institute of Technology, was recognized for fundamental discoveries of protein-glycan interactions pertinent to immunity, inflammation, host-microbe interactions and human development. 

Lisa Monteggia

, professor of pharmacology at Vanderbilt University, was recognized for contributions to the neurobiology of emotion, pioneering work identifying a causal link between neurotrophin signaling and antidepressant action, and contributions to understanding the synaptic plasticity mechanisms underlying the therapeutic effects of psychiatric treatments. 

Yang Shi

, professor and director of epigenetics at Oxford University and a member of the Ludwig Institute for Cancer Research, was recognized for the groundbreaking discovery that histone methylation is reversible and discovery of the first histone demethylase.